Drug interactions
Atazanavir + Buspirone
Severity: Moderate
Atazanavir and Buspirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a CYP3A4 inhibitor, can raise buspirone concentrations, increasing dizziness, drowsiness, nausea and risk of serotonergic effects.
What this interaction means in plain words
Atazanavir and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Buspirone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated first-pass and systemic metabolism of buspirone.
What to do
Start buspirone at a low dose and titrate cautiously, monitoring for adverse effects. Reduce the dose if sedation or dizziness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Buspirone?
MediHelp rates the interaction as moderate. Atazanavir and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, a CYP3A4 inhibitor, can raise buspirone concentrations, increasing dizziness, drowsiness, nausea and risk of serotonergic effects.
How serious is the interaction between Atazanavir and Buspirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start buspirone at a low dose and titrate cautiously, monitoring for adverse effects. Reduce the dose if sedation or dizziness develops.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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