Drug interactions
Atazanavir + Chlordiazepoxide-clidinium
Severity: Moderate
Atazanavir and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a boosted protease inhibitor, can raise chlordiazepoxide exposure. This may cause excessive sedation, confusion and respiratory depression, especially in older patients or with prolonged use.
What this interaction means in plain words
Atazanavir and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated metabolism of chlordiazepoxide by atazanavir.
What to do
Use the lowest effective chlordiazepoxide dose and monitor for oversedation and respiratory depression. Consider a benzodiazepine less dependent on CYP3A4, such as lorazepam, if therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Atazanavir and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, a boosted protease inhibitor, can raise chlordiazepoxide exposure. This may cause excessive sedation, confusion and respiratory depression, especially in older patients or with prolonged use.
How serious is the interaction between Atazanavir and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective chlordiazepoxide dose and monitor for oversedation and respiratory depression. Consider a benzodiazepine less dependent on CYP3A4, such as lorazepam, if therapy is needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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