Drug interactions
Atazanavir + Cilostazol
Severity: Moderate
Atazanavir and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise cilostazol concentrations. This increases the risk of cilostazol effects such as headache, tachycardia, palpitations and diarrhea.
What this interaction means in plain words
Atazanavir and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Cilostazol belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated cilostazol metabolism by atazanavir.
What to do
Consider reducing cilostazol to 50 mg twice daily, as labeling advises for strong CYP3A4 inhibitors, and monitor for tachycardia and headache.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Cilostazol?
MediHelp rates the interaction as moderate. Atazanavir and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise cilostazol concentrations. This increases the risk of cilostazol effects such as headache, tachycardia, palpitations and diarrhea.
How serious is the interaction between Atazanavir and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily, as labeling advises for strong CYP3A4 inhibitors, and monitor for tachycardia and headache.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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