Drug interactions
Atazanavir + Clopidogrel
Severity: Moderate
Atazanavir and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which participates in clopidogrel activation, and could modestly reduce formation of the active metabolite. The clinical significance is uncertain, since CYP2C19 is the major activating enzyme.
What this interaction means in plain words
Atazanavir and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Clopidogrel belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition may reduce clopidogrel bioactivation.
What to do
No routine dose change is established. Consider monitoring for reduced antiplatelet effect in high-risk patients, such as after stenting, and consider alternatives if concerned.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Clopidogrel?
MediHelp rates the interaction as moderate. Atazanavir and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, which participates in clopidogrel activation, and could modestly reduce formation of the active metabolite. The clinical significance is uncertain, since CYP2C19 is the major activating enzyme.
How serious is the interaction between Atazanavir and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is established. Consider monitoring for reduced antiplatelet effect in high-risk patients, such as after stenting, and consider alternatives if concerned.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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