Drug interactions
Atazanavir + Desipramine
Severity: Moderate
Atazanavir and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir may raise desipramine concentrations, which could increase tricyclic adverse effects such as anticholinergic effects, sedation and cardiac conduction changes. Atazanavir itself can prolong the PR interval, adding to cardiac concern.
What this interaction means in plain words
Atazanavir and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Desipramine belongs to Central Nervous System.
Why it happens
Possible inhibition of desipramine metabolism; the exact mechanism is not firmly established.
What to do
Start desipramine at a low dose and titrate according to response and tolerability. Consider monitoring ECG and desipramine levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Desipramine?
MediHelp rates the interaction as moderate. Atazanavir and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir may raise desipramine concentrations, which could increase tricyclic adverse effects such as anticholinergic effects, sedation and cardiac conduction changes. Atazanavir itself can prolong the PR interval, adding to cardiac concern.
How serious is the interaction between Atazanavir and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start desipramine at a low dose and titrate according to response and tolerability. Consider monitoring ECG and desipramine levels where available.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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