Drug interactions
Atazanavir + Diclofenac
Severity: Minor
Atazanavir and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibition by ritonavir-boosted atazanavir might raise diclofenac exposure modestly, though diclofenac is mainly metabolised by CYP2C9. The clinical relevance is uncertain.
What this interaction means in plain words
Atazanavir and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Diclofenac belongs to Musculoskeletal.
Why it happens
Possible inhibition of minor CYP3A4-mediated diclofenac metabolism, with CYP2C9 as the primary pathway.
What to do
No empirical dose change is needed; monitor for NSAID adverse effects such as gastrointestinal and renal events.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Diclofenac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Diclofenac?
MediHelp rates the interaction as minor. Atazanavir and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Strong CYP3A4 inhibition by ritonavir-boosted atazanavir might raise diclofenac exposure modestly, though diclofenac is mainly metabolised by CYP2C9. The clinical relevance is uncertain.
How serious is the interaction between Atazanavir and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for NSAID adverse effects such as gastrointestinal and renal events.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
