Drug interactions
Atazanavir + Eszopiclone
Severity: Moderate
Atazanavir and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which is a major route of eszopiclone elimination, so eszopiclone exposure rises. This can increase sedation, next-day impairment and complex sleep behaviors.
What this interaction means in plain words
Atazanavir and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Eszopiclone belongs to Central Nervous System.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of eszopiclone.
What to do
Start eszopiclone at 1 mg and do not exceed 2 mg; monitor for excessive sedation and next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Eszopiclone?
MediHelp rates the interaction as moderate. Atazanavir and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, which is a major route of eszopiclone elimination, so eszopiclone exposure rises. This can increase sedation, next-day impairment and complex sleep behaviors.
How serious is the interaction between Atazanavir and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and do not exceed 2 mg; monitor for excessive sedation and next-day impairment.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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