Drug interactions
Atazanavir + Flutamide
Severity: Minor
Atazanavir and Flutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise flutamide concentrations. Higher exposure could increase the risk of flutamide adverse effects, including liver toxicity.
What this interaction means in plain words
Atazanavir and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Flutamide belongs to Endocrine.
Why it happens
Atazanavir inhibits CYP3A4, reducing flutamide metabolism.
What to do
Monitor liver function tests periodically during coadministration. Stop flutamide if signs of liver injury develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flutamide
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Flutamide?
MediHelp rates the interaction as minor. Atazanavir and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and may raise flutamide concentrations. Higher exposure could increase the risk of flutamide adverse effects, including liver toxicity.
How serious is the interaction between Atazanavir and Flutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests periodically during coadministration. Stop flutamide if signs of liver injury develop.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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