Drug interactions
Atazanavir + Formoterol-mometasone
Severity: Moderate
Atazanavir and Formoterol-mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a boosted CYP3A4 inhibitor, can raise systemic mometasone exposure. This may lead to Cushing's syndrome and adrenal suppression with prolonged use.
What this interaction means in plain words
Atazanavir and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Formoterol-mometasone belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of mometasone increases systemic corticosteroid exposure.
What to do
Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term use. If combined, use the lowest effective mometasone dose and monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Formoterol-mometasone?
MediHelp rates the interaction as moderate. Atazanavir and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, a boosted CYP3A4 inhibitor, can raise systemic mometasone exposure. This may lead to Cushing's syndrome and adrenal suppression with prolonged use.
How serious is the interaction between Atazanavir and Formoterol-mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term use. If combined, use the lowest effective mometasone dose and monitor for corticosteroid adverse effects.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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