Drug interactions
Atazanavir + Glimepiride
Severity: Minor
Atazanavir and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce glycemic control achieved with glimepiride. Atazanavir has less metabolic impact than other protease inhibitors, so the effect is variable.
What this interaction means in plain words
Atazanavir and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Glimepiride belongs to Endocrine.
Why it happens
Protease inhibitors can induce insulin resistance and impair glucose handling, opposing the effect of the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting or changing antiretroviral therapy and titrate glimepiride as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Glimepiride?
MediHelp rates the interaction as minor. Atazanavir and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce glycemic control achieved with glimepiride. Atazanavir has less metabolic impact than other protease inhibitors, so the effect is variable.
How serious is the interaction between Atazanavir and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing antiretroviral therapy and titrate glimepiride as needed.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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