Drug interactions
Atazanavir + Maprotiline
Severity: Moderate
Atazanavir and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, particularly when boosted with ritonavir, may increase maprotiline concentrations, raising the risk of seizures, anticholinergic effects and cardiac conduction problems.
What this interaction means in plain words
Atazanavir and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Maprotiline belongs to Central Nervous System.
Why it happens
Inhibition of CYP-mediated metabolism of maprotiline, mainly CYP2D6 with ritonavir boosting.
What to do
Monitor for tricyclic-type toxicity and consider a lower maprotiline dose. Obtain an ECG if cardiac risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Maprotiline?
MediHelp rates the interaction as moderate. Atazanavir and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, particularly when boosted with ritonavir, may increase maprotiline concentrations, raising the risk of seizures, anticholinergic effects and cardiac conduction problems.
How serious is the interaction between Atazanavir and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic-type toxicity and consider a lower maprotiline dose. Obtain an ECG if cardiac risk factors exist.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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