Drug interactions
Atazanavir + Nebivolol
Severity: Moderate
Atazanavir and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir prolongs the PR interval and, together with beta-blockers, may increase the risk of bradycardia and AV block. Nebivolol exposure may also rise because atazanavir inhibits CYP3A4 and nebivolol is metabolized by CYP2D6 and other pathways, though this is less established.
What this interaction means in plain words
Atazanavir and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Nebivolol belongs to Cardiovascular.
Why it happens
Additive effects on AV nodal conduction, with possible modest pharmacokinetic increase in beta-blocker exposure.
What to do
Monitor heart rate, blood pressure and ECG (PR interval) when starting or adjusting either drug, and reduce the nebivolol dose if bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Nebivolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Nebivolol?
MediHelp rates the interaction as moderate. Atazanavir and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir prolongs the PR interval and, together with beta-blockers, may increase the risk of bradycardia and AV block. Nebivolol exposure may also rise because atazanavir inhibits CYP3A4 and nebivolol is metabolized by CYP2D6 and other pathways, though this is less established.
How serious is the interaction between Atazanavir and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG (PR interval) when starting or adjusting either drug, and reduce the nebivolol dose if bradycardia or conduction delay occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
