Drug interactions
Atazanavir + Nicardipine
Severity: Moderate
Atazanavir and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise nicardipine concentrations, increasing the risk of hypotension, tachycardia and oedema. Atazanavir also may prolong PR interval, which adds concern with other cardioactive drugs.
What this interaction means in plain words
Atazanavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated nicardipine metabolism by atazanavir (more so when boosted).
What to do
Start with a lower nicardipine dose and titrate to blood pressure. Monitor ECG when PR prolongation is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Nicardipine?
MediHelp rates the interaction as moderate. Atazanavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise nicardipine concentrations, increasing the risk of hypotension, tachycardia and oedema. Atazanavir also may prolong PR interval, which adds concern with other cardioactive drugs.
How serious is the interaction between Atazanavir and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower nicardipine dose and titrate to blood pressure. Monitor ECG when PR prolongation is a concern.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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