Drug interactions
Atazanavir + Nimodipine
Severity: Moderate
Atazanavir and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise nimodipine concentrations. This may lead to excessive hypotension, flushing and headache.
What this interaction means in plain words
Atazanavir and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by atazanavir reduces nimodipine first-pass and systemic metabolism.
What to do
Monitor blood pressure closely and consider reducing the nimodipine dose. Be aware that boosting with ritonavir or cobicistat increases the magnitude of this effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Nimodipine?
MediHelp rates the interaction as moderate. Atazanavir and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise nimodipine concentrations. This may lead to excessive hypotension, flushing and headache.
How serious is the interaction between Atazanavir and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider reducing the nimodipine dose. Be aware that boosting with ritonavir or cobicistat increases the magnitude of this effect.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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