Drug interactions
Atazanavir + Sertraline
Severity: Moderate
Atazanavir and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may modestly increase sertraline concentrations, increasing serotonergic side effects. The effect is usually manageable with dose titration.
What this interaction means in plain words
Atazanavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Sertraline belongs to Central Nervous System.
Why it happens
Atazanavir inhibits CYP3A4, one of the enzymes contributing to sertraline metabolism.
What to do
Titrate sertraline to clinical response starting from a low dose. Monitor for nausea, tremor, agitation and other serotonergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Sertraline?
MediHelp rates the interaction as moderate. Atazanavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may modestly increase sertraline concentrations, increasing serotonergic side effects. The effect is usually manageable with dose titration.
How serious is the interaction between Atazanavir and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sertraline to clinical response starting from a low dose. Monitor for nausea, tremor, agitation and other serotonergic effects.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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