Drug interactions
Atazanavir + Sitagliptin
Severity: Minor
Atazanavir and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with sitagliptin. Atazanavir is among the protease inhibitors with a relatively small metabolic effect, so the impact is variable.
What this interaction means in plain words
Atazanavir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic opposition: protease inhibitors may impair insulin sensitivity, counteracting the glucose-lowering effect of sitagliptin.
What to do
Monitor blood glucose and HbA1c after starting or stopping the antiretroviral. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Sitagliptin?
MediHelp rates the interaction as minor. Atazanavir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with sitagliptin. Atazanavir is among the protease inhibitors with a relatively small metabolic effect, so the impact is variable.
How serious is the interaction between Atazanavir and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping the antiretroviral. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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