Drug interactions
Atazanavir + Terbinafine
Severity: Minor
Atazanavir and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is cleared by several CYP enzymes, with CYP3A4 as a minor route. Atazanavir inhibits CYP3A4 and could modestly raise terbinafine exposure, but the clinical effect is expected to be small.
What this interaction means in plain words
Atazanavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Terbinafine belongs to Anti Fungals.
Why it happens
Atazanavir inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No routine dose change is needed. Watch for terbinafine adverse effects such as gastrointestinal upset, rash or liver enzyme elevation during prolonged courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Terbinafine?
MediHelp rates the interaction as minor. Atazanavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbinafine is cleared by several CYP enzymes, with CYP3A4 as a minor route. Atazanavir inhibits CYP3A4 and could modestly raise terbinafine exposure, but the clinical effect is expected to be small.
How serious is the interaction between Atazanavir and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for terbinafine adverse effects such as gastrointestinal upset, rash or liver enzyme elevation during prolonged courses.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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