Drug interactions
Crizotinib + Vinblastine
Severity: Major
Crizotinib and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein, both of which clear vinblastine. Higher vinblastine levels may increase myelosuppression, neurotoxicity and constipation.
What this interaction means in plain words
Crizotinib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism and P-glycoprotein efflux of vinblastine.
What to do
Monitor blood counts and for neurotoxicity and ileus, and reduce the vinblastine dose if toxicity develops. Consider alternatives to crizotinib where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Vinblastine?
MediHelp rates the interaction as major. Crizotinib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib inhibits CYP3A4 and P-glycoprotein, both of which clear vinblastine. Higher vinblastine levels may increase myelosuppression, neurotoxicity and constipation.
How serious is the interaction between Crizotinib and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity and ileus, and reduce the vinblastine dose if toxicity develops. Consider alternatives to crizotinib where feasible.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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