Drug interactions
Atazanavir + Ziprasidone
Severity: Moderate
Atazanavir and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, one of the pathways that clears ziprasidone, which can raise ziprasidone levels. Atazanavir itself can prolong PR and QT intervals, so the cardiac effect may be additive.
What this interaction means in plain words
Atazanavir and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Ziprasidone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by ritonavir-boosted or unboosted atazanavir, plus additive effects on cardiac conduction.
What to do
Monitor ECG and for adverse effects such as sedation or QT prolongation when starting atazanavir. Reduce the ziprasidone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Ziprasidone?
MediHelp rates the interaction as moderate. Atazanavir and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, one of the pathways that clears ziprasidone, which can raise ziprasidone levels. Atazanavir itself can prolong PR and QT intervals, so the cardiac effect may be additive.
How serious is the interaction between Atazanavir and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for adverse effects such as sedation or QT prolongation when starting atazanavir. Reduce the ziprasidone dose if needed.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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