Drug interactions
Atenolol + Digoxin
Severity: Moderate
Atenolol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV nodal conduction, so together they can cause bradycardia and AV block. The risk is highest in older patients or those with conduction disease.
What this interaction means in plain words
Atenolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Additive slowing of AV nodal conduction through beta blockade and increased vagal tone from digoxin.
What to do
Monitor heart rate and ECG, particularly at initiation and after dose changes. Reduce or stop one drug if symptomatic bradycardia or block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Atenolol with Digoxin?
MediHelp rates the interaction as moderate. Atenolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow AV nodal conduction, so together they can cause bradycardia and AV block. The risk is highest in older patients or those with conduction disease.
How serious is the interaction between Atenolol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, particularly at initiation and after dose changes. Reduce or stop one drug if symptomatic bradycardia or block occurs.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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