Drug interactions
Atenolol + Hydrochlorothiazide
Severity: Minor
Atenolol and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs are commonly combined for hypertension and have additive blood pressure lowering. Thiazides may also modestly worsen glucose and lipid control and can cause hypokalaemia.
What this interaction means in plain words
Atenolol and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, with thiazide-related metabolic effects.
What to do
Monitor blood pressure, potassium and glucose in patients with diabetes or at risk of it. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Atenolol and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two drugs are commonly combined for hypertension and have additive blood pressure lowering. Thiazides may also modestly worsen glucose and lipid control and can cause hypokalaemia.
How serious is the interaction between Atenolol and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and glucose in patients with diabetes or at risk of it. No routine dose change is needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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