Drug interactions
Atenolol + Sevoflurane
Severity: Moderate
Atenolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane depress myocardial contractility and vasomotor tone, and beta-blockade blunts compensatory sympathetic responses. Together they can produce deeper hypotension and bradycardia during anesthesia.
What this interaction means in plain words
Atenolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular depression from vasodilation and negative inotropy with beta-adrenergic blockade.
What to do
Generally continue chronic beta-blocker perioperatively and monitor blood pressure and heart rate closely, titrating anesthetic depth and having vasopressors or anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Atenolol with Sevoflurane?
MediHelp rates the interaction as moderate. Atenolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane depress myocardial contractility and vasomotor tone, and beta-blockade blunts compensatory sympathetic responses. Together they can produce deeper hypotension and bradycardia during anesthesia.
How serious is the interaction between Atenolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue chronic beta-blocker perioperatively and monitor blood pressure and heart rate closely, titrating anesthetic depth and having vasopressors or anticholinergics available.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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