Drug interactions
Atenolol-chlorthalidone + Digoxin
Severity: Moderate
Atenolol-chlorthalidone and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol and digoxin both slow AV nodal conduction, so together they can cause marked bradycardia or heart block. Chlorthalidone-induced hypokalemia or hypomagnesemia can further increase digoxin toxicity risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Additive AV nodal slowing; diuretic-induced electrolyte depletion sensitizes the myocardium to digoxin.
What to do
Monitor heart rate, ECG, serum potassium, magnesium and digoxin levels. Correct electrolyte disturbances promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Digoxin?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atenolol and digoxin both slow AV nodal conduction, so together they can cause marked bradycardia or heart block. Chlorthalidone-induced hypokalemia or hypomagnesemia can further increase digoxin toxicity risk.
How serious is the interaction between Atenolol-chlorthalidone and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG, serum potassium, magnesium and digoxin levels. Correct electrolyte disturbances promptly.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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