Drug interactions
Atenolol-chlorthalidone + Hydrochlorothiazide
Severity: Moderate
Atenolol-chlorthalidone and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide duplicates the thiazide-type diuretic already provided by chlorthalidone. This adds to the risk of hypokalemia, hyponatremia, hyperuricemia and volume depletion without much extra antihypertensive benefit.
What this interaction means in plain words
Atenolol-chlorthalidone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive inhibition of the sodium-chloride cotransporter in the distal tubule.
What to do
Avoid combining two thiazide-type diuretics and stop the duplicate. If used together, monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Atenolol-chlorthalidone with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide duplicates the thiazide-type diuretic already provided by chlorthalidone. This adds to the risk of hypokalemia, hyponatremia, hyperuricemia and volume depletion without much extra antihypertensive benefit.
How serious is the interaction between Atenolol-chlorthalidone and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics and stop the duplicate. If used together, monitor electrolytes and renal function.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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