Drug interactions
Atenolol-chlorthalidone + Sotalol
Severity: Major
Atenolol-chlorthalidone and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a beta-blocker with class III antiarrhythmic activity, and adding atenolol duplicates beta-blockade. This increases the risk of bradycardia, hypotension and AV block, and chlorthalidone-related hypokalemia raises QT and torsades risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive beta-blockade, with sotalol-related QT prolongation worsened by diuretic-induced electrolyte loss.
What to do
Avoid combining with another beta-blocker. Monitor ECG, potassium and magnesium if sotalol is used with chlorthalidone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atenolol-chlorthalidone
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Sotalol?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a beta-blocker with class III antiarrhythmic activity, and adding atenolol duplicates beta-blockade. This increases the risk of bradycardia, hypotension and AV block, and chlorthalidone-related hypokalemia raises QT and torsades risk.
How serious is the interaction between Atenolol-chlorthalidone and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with another beta-blocker. Monitor ECG, potassium and magnesium if sotalol is used with chlorthalidone.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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