Drug interactions
Atenolol-chlorthalidone + Vitamin d
Severity: Moderate
Atenolol-chlorthalidone and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as chlorthalidone reduce urinary calcium excretion. Combined with vitamin D, which enhances calcium absorption, this can cause hypercalcemia, particularly with high doses or in renal impairment.
What this interaction means in plain words
Atenolol-chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Reduced renal calcium excretion from the thiazide plus increased intestinal calcium absorption from vitamin D.
What to do
Monitor serum calcium and renal function periodically, especially when doses are high or calcium supplements are also used. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Vitamin d
Frequently asked questions
Can I take Atenolol-chlorthalidone with Vitamin d?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as chlorthalidone reduce urinary calcium excretion. Combined with vitamin D, which enhances calcium absorption, this can cause hypercalcemia, particularly with high doses or in renal impairment.
How serious is the interaction between Atenolol-chlorthalidone and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, especially when doses are high or calcium supplements are also used. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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