Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Vitamin d
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce renal calcium excretion, and vitamin D increases intestinal calcium absorption. Together they may cause hypercalcemia, particularly with high-dose vitamin D or in patients with renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Reduced urinary calcium excretion by hydrochlorothiazide combined with increased calcium absorption from vitamin D.
What to do
Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Vitamin d
- Aluminum hydroxide + Vitamin d Major
- Amlodipine-olmesartan-hydrochlorothiazide + Vitamin d Moderate
- Atenolol-chlorthalidone + Vitamin d Moderate
- Calcium acetate + Vitamin d Moderate
- Calcium carbonate + Vitamin d Moderate
- Calcium chloride + Vitamin d Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Vitamin d?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce renal calcium excretion, and vitamin D increases intestinal calcium absorption. Together they may cause hypercalcemia, particularly with high-dose vitamin D or in patients with renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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