Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Vitamin d
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide reduces urinary calcium excretion, and vitamin D enhances intestinal calcium absorption. Together they can cause hypercalcemia, especially with high vitamin D doses, calcium supplements or renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazide-induced renal calcium reabsorption combined with vitamin D-enhanced calcium absorption.
What to do
Monitor serum calcium periodically, particularly with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Vitamin d
- Aluminum hydroxide + Vitamin d Major
- Amlodipine-hydrochlorothiazide-valsartan + Vitamin d Moderate
- Atenolol-chlorthalidone + Vitamin d Moderate
- Calcium acetate + Vitamin d Moderate
- Calcium carbonate + Vitamin d Moderate
- Calcium chloride + Vitamin d Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide reduces urinary calcium excretion, and vitamin D enhances intestinal calcium absorption. Together they can cause hypercalcemia, especially with high vitamin D doses, calcium supplements or renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, particularly with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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