Drug interactions
Calcium carbonate + Vitamin d
Severity: Moderate
Calcium carbonate and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, so combined use is often intended but can cause hypercalcemia, especially with high doses or renal impairment. Symptoms include nausea, polyuria, confusion and arrhythmias.
What this interaction means in plain words
Calcium carbonate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Vitamin D enhances intestinal calcium absorption and bone resorption, additively raising serum calcium.
What to do
Monitor serum calcium and renal function periodically, particularly with high doses or in renal disease. Reduce calcium or vitamin D if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Vitamin d
Frequently asked questions
Can I take Calcium carbonate with Vitamin d?
MediHelp rates the interaction as moderate. Calcium carbonate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combined use is often intended but can cause hypercalcemia, especially with high doses or renal impairment. Symptoms include nausea, polyuria, confusion and arrhythmias.
How serious is the interaction between Calcium carbonate and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, particularly with high doses or in renal disease. Reduce calcium or vitamin D if hypercalcemia develops.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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