Drug interactions
Atidarsagene autotemcel + Pneumococcal vaccine 13-valent
Severity: Moderate
Atidarsagene autotemcel and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atidarsagene autotemcel involves myeloablative conditioning followed by hematologic reconstitution, during which immune responses to vaccines are unreliable. Vaccine safety and effectiveness around this therapy have not been studied. Vaccination close to conditioning may be ineffective and confound assessment of adverse events.
What this interaction means in plain words
Atidarsagene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atidarsagene autotemcel belongs to Miscellaneous; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Myeloablative conditioning and hematopoietic reconstitution impair immune response to vaccination.
What to do
Give age-appropriate vaccines, including pneumococcal, before conditioning (not within about 6 weeks before it). Defer vaccination until hematologic recovery after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Atidarsagene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atidarsagene autotemcel involves myeloablative conditioning followed by hematologic reconstitution, during which immune responses to vaccines are unreliable. Vaccine safety and effectiveness around this therapy have not been studied. Vaccination close to conditioning may be ineffective and confound assessment of adverse events.
How serious is the interaction between Atidarsagene autotemcel and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give age-appropriate vaccines, including pneumococcal, before conditioning (not within about 6 weeks before it). Defer vaccination until hematologic recovery after treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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