Drug interactions
Atogepant + Cyclosporin
Severity: Moderate
Atogepant and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits OATP1B1 and other transporters and can raise atogepant concentrations. This may increase atogepant adverse effects such as constipation and nausea.
What this interaction means in plain words
Atogepant and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits OATP-mediated hepatic uptake of atogepant, increasing systemic exposure.
What to do
Limit atogepant to the lower labeled doses, 10 mg or 30 mg once daily, when given with OATP inhibitors. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Cyclosporin?
MediHelp rates the interaction as moderate. Atogepant and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits OATP1B1 and other transporters and can raise atogepant concentrations. This may increase atogepant adverse effects such as constipation and nausea.
How serious is the interaction between Atogepant and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the lower labeled doses, 10 mg or 30 mg once daily, when given with OATP inhibitors. Monitor tolerability.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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