Drug interactions
Atogepant + Efavirenz
Severity: Moderate
Atogepant and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a moderate to strong CYP3A4 inducer and can lower atogepant exposure, which may reduce migraine prevention efficacy.
What this interaction means in plain words
Atogepant and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
CYP3A4 induction by efavirenz increases atogepant metabolism.
What to do
Use an atogepant dose of 30 mg or 60 mg once daily during efavirenz co-therapy, as labeling advises for CYP3A4 inducers. Monitor migraine control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Efavirenz?
MediHelp rates the interaction as moderate. Atogepant and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz is a moderate to strong CYP3A4 inducer and can lower atogepant exposure, which may reduce migraine prevention efficacy.
How serious is the interaction between Atogepant and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an atogepant dose of 30 mg or 60 mg once daily during efavirenz co-therapy, as labeling advises for CYP3A4 inducers. Monitor migraine control.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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