Drug interactions
Atogepant + Erythromycin
Severity: Moderate
Atogepant and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can inhibit OATP transporters and CYP3A4, increasing atogepant exposure. This may increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of OATP1B1 uptake and CYP3A4 metabolism of atogepant.
What to do
Limit atogepant to 10 mg or 30 mg once daily during erythromycin treatment, according to the indication. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Erythromycin?
MediHelp rates the interaction as moderate. Atogepant and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can inhibit OATP transporters and CYP3A4, increasing atogepant exposure. This may increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to 10 mg or 30 mg once daily during erythromycin treatment, according to the indication. Monitor tolerability.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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