Drug interactions
Atogepant + Glyburide-metformin
Severity: Minor
Atogepant and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in atogepant exposure is unlikely. Any interaction is theoretical and the practical impact is minimal.
What this interaction means in plain words
Atogepant and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Glyburide is a CYP3A4 substrate with no established inhibitory effect, so a pharmacokinetic interaction is not substantiated.
What to do
No dose change is needed; monitor for atogepant adverse effects such as constipation and nausea as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atogepant and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Glyburide-metformin?
MediHelp rates the interaction as minor. Atogepant and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in atogepant exposure is unlikely. Any interaction is theoretical and the practical impact is minimal.
How serious is the interaction between Atogepant and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for atogepant adverse effects such as constipation and nausea as usual.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
