Drug interactions
Atogepant + Lorlatinib
Severity: Moderate
Atogepant and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower atogepant concentrations. Reduced exposure could lessen migraine prevention efficacy.
What this interaction means in plain words
Atogepant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing atogepant metabolism.
What to do
Use the labeled atogepant dose for CYP3A4 inducers (30 mg or 60 mg daily for chronic migraine or episodic respectively as per label) and assess migraine control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Lorlatinib?
MediHelp rates the interaction as moderate. Atogepant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower atogepant concentrations. Reduced exposure could lessen migraine prevention efficacy.
How serious is the interaction between Atogepant and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled atogepant dose for CYP3A4 inducers (30 mg or 60 mg daily for chronic migraine or episodic respectively as per label) and assess migraine control.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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