Drug interactions
Atogepant + Metformin-pioglitazone
Severity: Minor
Atogepant and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is a weak CYP3A4 inducer in vitro, but no clinically meaningful reduction in atogepant exposure has been established. Any effect is theoretical.
What this interaction means in plain words
Atogepant and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by pioglitazone, not shown to be clinically relevant.
What to do
No action is needed; assess migraine prevention efficacy as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Atogepant and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is a weak CYP3A4 inducer in vitro, but no clinically meaningful reduction in atogepant exposure has been established. Any effect is theoretical.
How serious is the interaction between Atogepant and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed; assess migraine prevention efficacy as usual.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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