Drug interactions
Atogepant + Nilotinib
Severity: Moderate
Atogepant and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 to a moderate degree and may raise atogepant concentrations. Higher exposure could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated atogepant metabolism by nilotinib.
What to do
Review atogepant labeling for dose limits with CYP3A4 inhibitors and use the lower recommended dose if applicable. Monitor for tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Nilotinib?
MediHelp rates the interaction as moderate. Atogepant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 to a moderate degree and may raise atogepant concentrations. Higher exposure could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review atogepant labeling for dose limits with CYP3A4 inhibitors and use the lower recommended dose if applicable. Monitor for tolerability.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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