Drug interactions
Atogepant + Pazopanib
Severity: Moderate
Atogepant and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits CYP3A4 and OATP1B1 and may increase atogepant exposure. This could increase atogepant adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and OATP-mediated hepatic uptake by pazopanib, raising atogepant concentrations.
What to do
Limit atogepant to 10 mg or 30 mg once daily during concurrent pazopanib therapy for migraine prevention. Monitor for tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Pazopanib?
MediHelp rates the interaction as moderate. Atogepant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits CYP3A4 and OATP1B1 and may increase atogepant exposure. This could increase atogepant adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to 10 mg or 30 mg once daily during concurrent pazopanib therapy for migraine prevention. Monitor for tolerability.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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