Drug interactions
Atomoxetine + Fedratinib
Severity: Moderate
Atomoxetine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP2D6 inhibitor and may raise atomoxetine concentrations, increasing adverse effects such as tachycardia, hypertension and insomnia.
What this interaction means in plain words
Atomoxetine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated atomoxetine metabolism by fedratinib.
What to do
Monitor heart rate, blood pressure and tolerability, and reduce the atomoxetine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Atomoxetine with Fedratinib?
MediHelp rates the interaction as moderate. Atomoxetine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP2D6 inhibitor and may raise atomoxetine concentrations, increasing adverse effects such as tachycardia, hypertension and insomnia.
How serious is the interaction between Atomoxetine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and tolerability, and reduce the atomoxetine dose if adverse effects appear.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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