Drug interactions
Atomoxetine + Fluconazole
Severity: Moderate
Atomoxetine and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval and atomoxetine has been associated with QT effects, so combined use may raise arrhythmia risk. The risk is higher with other risk factors such as electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Atomoxetine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG in at-risk patients and correct potassium and magnesium abnormalities. Monitor for palpitations or syncope and reassess therapy if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Fluconazole?
MediHelp rates the interaction as moderate. Atomoxetine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval and atomoxetine has been associated with QT effects, so combined use may raise arrhythmia risk. The risk is higher with other risk factors such as electrolyte disturbance or cardiac disease.
How serious is the interaction between Atomoxetine and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in at-risk patients and correct potassium and magnesium abnormalities. Monitor for palpitations or syncope and reassess therapy if QTc lengthens.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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