Drug interactions
Atomoxetine + Mirtazapine
Severity: Minor
Atomoxetine and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been associated with QT prolongation in overdose and rare cases at therapeutic doses, and atomoxetine may have a minor additive effect. Both can also affect heart rate and blood pressure, but significant interaction is uncommon.
What this interaction means in plain words
Atomoxetine and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atomoxetine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible additive effects on cardiac repolarization; no established pharmacokinetic interaction.
What to do
No routine adjustment is needed; consider an ECG if the patient has other QT risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Mirtazapine?
MediHelp rates the interaction as minor. Atomoxetine and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine has been associated with QT prolongation in overdose and rare cases at therapeutic doses, and atomoxetine may have a minor additive effect. Both can also affect heart rate and blood pressure, but significant interaction is uncommon.
How serious is the interaction between Atomoxetine and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider an ECG if the patient has other QT risk factors. Monitor for palpitations or syncope.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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