Drug interactions
Atomoxetine + Ondansetron
Severity: Moderate
Atomoxetine and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine has been linked to QT prolongation, mainly in overdose or in poor CYP2D6 metabolizers. With ondansetron the additive effect may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Atomoxetine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check the ECG and electrolytes in patients with cardiac risk factors. Use the lowest effective ondansetron dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Ondansetron?
MediHelp rates the interaction as moderate. Atomoxetine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine has been linked to QT prolongation, mainly in overdose or in poor CYP2D6 metabolizers. With ondansetron the additive effect may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Atomoxetine and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes in patients with cardiac risk factors. Use the lowest effective ondansetron dose.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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