Drug interactions
Atomoxetine + Ranolazine
Severity: Moderate
Atomoxetine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits CYP2D6 and may raise atomoxetine exposure, particularly in extensive metabolizers. Both agents can also prolong the QT interval, so the risk of QT prolongation and increased adrenergic effects is greater.
What this interaction means in plain words
Atomoxetine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by ranolazine reduces atomoxetine clearance, combined with additive QT prolongation.
What to do
Monitor heart rate, blood pressure and ECG, and consider a lower atomoxetine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Ranolazine?
MediHelp rates the interaction as moderate. Atomoxetine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits CYP2D6 and may raise atomoxetine exposure, particularly in extensive metabolizers. Both agents can also prolong the QT interval, so the risk of QT prolongation and increased adrenergic effects is greater.
How serious is the interaction between Atomoxetine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and consider a lower atomoxetine dose if adverse effects emerge.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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