Drug interactions
Atomoxetine + Risperidone
Severity: Moderate
Atomoxetine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can prolong the QT interval modestly, and atomoxetine may add to this effect. Risperidone is also partly metabolized by CYP2D6, but atomoxetine is not a meaningful CYP2D6 inhibitor, so the main concern is pharmacodynamic.
What this interaction means in plain words
Atomoxetine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG if other QT risk factors are present and keep electrolytes normal. Monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Atomoxetine with Risperidone?
MediHelp rates the interaction as moderate. Atomoxetine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can prolong the QT interval modestly, and atomoxetine may add to this effect. Risperidone is also partly metabolized by CYP2D6, but atomoxetine is not a meaningful CYP2D6 inhibitor, so the main concern is pharmacodynamic.
How serious is the interaction between Atomoxetine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG if other QT risk factors are present and keep electrolytes normal. Monitor blood pressure and heart rate.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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