Drug interactions
Atomoxetine + Sevoflurane
Severity: Moderate
Atomoxetine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval, and atomoxetine may add to this effect. Atomoxetine's cardiovascular stimulation may also complicate hemodynamic control during anesthesia.
What this interaction means in plain words
Atomoxetine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with sympathomimetic effects from atomoxetine.
What to do
Inform the anesthesia team and correct electrolytes before surgery. Monitor ECG and hemodynamics during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Atomoxetine with Sevoflurane?
MediHelp rates the interaction as moderate. Atomoxetine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval, and atomoxetine may add to this effect. Atomoxetine's cardiovascular stimulation may also complicate hemodynamic control during anesthesia.
How serious is the interaction between Atomoxetine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and correct electrolytes before surgery. Monitor ECG and hemodynamics during anesthesia.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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