Drug interactions
Atomoxetine + Sotalol
Severity: Moderate
Atomoxetine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine has been associated with QT prolongation and can raise heart rate and blood pressure, while sotalol prolongs QT and slows the heart. The combination may raise arrhythmia risk, particularly with other risk factors.
What this interaction means in plain words
Atomoxetine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Possible additive QT prolongation; atomoxetine's effect is modest.
What to do
Monitor ECG, heart rate and blood pressure, and correct electrolyte abnormalities. Consider an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Sotalol?
MediHelp rates the interaction as moderate. Atomoxetine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine has been associated with QT prolongation and can raise heart rate and blood pressure, while sotalol prolongs QT and slows the heart. The combination may raise arrhythmia risk, particularly with other risk factors.
How serious is the interaction between Atomoxetine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure, and correct electrolyte abnormalities. Consider an alternative if QTc becomes prolonged.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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