Drug interactions
Atomoxetine + Trazodone
Severity: Moderate
Atomoxetine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has been associated with QT prolongation and ventricular arrhythmias, and atomoxetine may add to this effect. Both drugs also act on monoaminergic systems, which may increase cardiovascular stimulation.
What this interaction means in plain words
Atomoxetine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for palpitations or syncope and review the need for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Atomoxetine with Trazodone?
MediHelp rates the interaction as moderate. Atomoxetine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has been associated with QT prolongation and ventricular arrhythmias, and atomoxetine may add to this effect. Both drugs also act on monoaminergic systems, which may increase cardiovascular stimulation.
How serious is the interaction between Atomoxetine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for palpitations or syncope and review the need for both drugs.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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