Drug interactions
Atomoxetine + Valbenazine
Severity: Moderate
Atomoxetine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and atomoxetine may add to this. Its active metabolite is cleared partly via CYP2D6, which atomoxetine does not inhibit meaningfully, so the main concern is QT.
What this interaction means in plain words
Atomoxetine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation.
What to do
Obtain an ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Atomoxetine with Valbenazine?
MediHelp rates the interaction as moderate. Atomoxetine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong the QT interval at higher exposures, and atomoxetine may add to this. Its active metabolite is cleared partly via CYP2D6, which atomoxetine does not inhibit meaningfully, so the main concern is QT.
How serious is the interaction between Atomoxetine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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