Drug interactions
Deutetrabenazine + Valbenazine
Severity: Contraindicated
Deutetrabenazine and Valbenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
What this interaction means in plain words
Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Duplicate VMAT2 inhibition causes additive pharmacodynamic effects and excessive monoamine depletion.
What to do
Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deutetrabenazine and Valbenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Other interactions of Valbenazine
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
- Cisapride + Valbenazine Major
Frequently asked questions
Can I take Deutetrabenazine with Valbenazine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
How serious is the interaction between Deutetrabenazine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
What other medicines interact with Deutetrabenazine?
MediHelp also lists interactions of Deutetrabenazine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Deutetrabenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
