Drug interactions
Carbamazepine + Valbenazine
Severity: Major
Carbamazepine and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine lowers valbenazine and its active metabolite exposure substantially. This can cause loss of efficacy in tardive dyskinesia or chorea.
What this interaction means in plain words
Carbamazepine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Strong CYP3A4 induction by carbamazepine increases the clearance of valbenazine and its active metabolite.
What to do
Avoid the combination as recommended in valbenazine labeling. Consider an alternative anticonvulsant if clinically feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Cisapride + Valbenazine Major
Frequently asked questions
Can I take Carbamazepine with Valbenazine?
MediHelp rates the interaction as major. Carbamazepine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine lowers valbenazine and its active metabolite exposure substantially. This can cause loss of efficacy in tardive dyskinesia or chorea.
How serious is the interaction between Carbamazepine and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as recommended in valbenazine labeling. Consider an alternative anticonvulsant if clinically feasible.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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